Alternating Hemiplegia of Childhood (AHC) » Prevalence of AHC
Alternating Hemiplegia of Childhood is a rare condition that can affect both, males and females. The majority of the known cases are sporadic (de novo mutations). AHC cases are scattered all over the world. The disease commences in early infancy and persists throughout the entire life of the patients. Most of the reported cases are of young age children, very little is still known of adults living with AHC.
Estimated prevalence of AHC in Denmark comes to 1 per 100,000 children
Through a nationwide survey among the Danish paediatric population, Hoei-Hansen et al 2013 identified 10 patients which fulfilled the clinical diagnostic criteria for AHC, thus estimating prevalence of AHC of approximately 1:100,000.
In spite of its characteristic symptoms, Alternating Hemiplegia of Childhood is still an under-diagnosed syndrome. Molecular genetic tests for ATP1A3 mutations are available to help establish and/or confirm AHC diagnosis.